Trippier felt his hamstring during Wednesday’s FA Cup loss to Tottenham, a game captain Shackell missed with a calf problem.
Kevin Long (knee), Stephen Ward (ankle) and Matt Taylor (Achilles) are all sidelined.
Crystal Palace are set to hand a debut to loan signing Yaya Sanogo.
The Arsenal striker will face competition to start up front from fit-again Marouane Chamakh, however, while midfielder James McArthur has beaten his foot problem.
New Palace boss Alan Pardew has no fresh injury concerns, and could hand Wilfried Zaha a start.