Midfielders Mehdi Abeid (foot), Siem de Jong and Gabriel Obertan (both thigh) and Rolando Aarons (hamstring) are all on the comeback trail, but none are expected to make the squad for this game.
Jonas Gutierrez’s continues his battle for fitness after recovering from testicular cancer, while goalkeepers Rob Elliot (thigh) and Jak Alnwick (shoulder), defender Steven Taylor (Achilles), utility man Ryan Taylor (knee) and striker Adam Armstrong (foot) are still out, while Cheick Tiote and Papiss Cisse are away on African Nations Cup duty.
Victor Wanyama, Morgan Schneiderlin and Toby Alderweireld are among those that will miss out for Southampton.
Wanyama will miss up to five weeks with a hamstring injury sustained in Wednesday’s FA Cup third-round replay at Ipswich – a match fellow defensive midfielder Schneiderlin missed with an adductor strain, which also rules him out of the St James’ Park trip.
Alderweireld is sidelined with a hamstring strain, seeing him join Sam Gallagher and Jay Rodriguez in the treatment room, while Maya Yoshida, Sadio Mane and Emmanuel Mayuka have international commitments.