In front of a record 52,633 crowd in Adelaide, the table-topping home side disappointed with Maddinson smashing five sixes in his knock ??? taking his tally in the competition to 16, five clear of the next best, the Strikers??? Tim Ludeman.
Maddinson ??? batting at three rather than his usual opening slot ??? built his innings brilliantly. He had scored just 26 runs coming from his first 28 balls before his onslaught took the Sixers to a score of 181-4.
The Strikers fell well short, with only tailender Ben Laughlin (22) passing 20 with some late slogging as the Strikers were all out for 94 in the 15th over.
Michael Lumb (32 off 19 deliveries) got the Sixers of to another strong start, this time with a new partner at the top of the order, Riki Wessels, contributing a run-a-ball 24.
But when the Nottinghamshire left-hander was run-out in the fifth over, the Sixers could only manage 37 runs from the next seven overs.
Shaun Tait accounted for Wessels in that spell with some terrific fast bowling, mixing in well-directed short balls with toe-crushing yorkers ??? one of which bowled Wessels.
But Maddinson had played himself in at the other end and launched his counter-attack with two sixes off Adam Zampa ??? the second a massive hit over midwicket.
He also ruined Tait???s figures taking 17 runs from his final over including another huge six, this time over the square-leg fence.
Kane Richardson bowled Maddinson in the 18th over and Ben Laughlin picked up Jordan Silk (three) lbw five balls later, but it was too little too late with the Sixers setting a challenging 182 to win.
Ludeman (15) didn???t come off at the top of the order this time for the Strikers, cutting a short-wide long-hop straight to Lumb at extra cover.
By that point the Strikers were 28-3 in the fifth over having already lost Craig Simmons (five) and Travis Head (eight) early on.
Brad Hodge ??? returning after a month out with a broken arm ??? had the full weight of the home support resting on his shoulders and although he managed three fours in a 14-ball 20, his wicket ??? top-edging one off Sean Abbott ??? signalled the beginning of the end.
Doug Bollinger took 3-21 in dismissing the tail, and Brett Lee (1-16) took another wicket as he looks to end his career with a Big Bash final win for the Sixers.
Sydney’s win over the Strikers means that once again no team who has finished top of the Big Bash League table has won the competition.