With the Scorchers needing one run off three balls to overhaul the Sixers??? 147-5, Lee bowled Nathan Coulter-Nile and Sam Whiteman to earn the chance of signing off with a hat-trick.
Yasir Arafat got bat on the final delivery but would have been run out by yards had Sixers skipper Moses Henriques gathered the ball cleanly at the non-striker???s end; instead he broke the wicket without the ball to hand the Scorchers back-to-back titles.
The defeat was tough on Henriques, who bowled four tight overs for 21 after hitting 77 off 57 balls and putting on 98 off 10.4 overs with Ryan Carters (35no off 25) to rescue the Sixers from 49-4.
His side was on the back foot almost immediately after choosing to bat as openers Michael Lumb and Riki Wessels were bowled for single figures, by Nathan Coulter-Nile (1-32) and Jason Behrendorff (1-19) respectively.
Nic Maddinson, who struck 85 in the semi-final, rallied with 19 off 22 but when he was cleaned out by a full Arafat delivery and Brad Hogg bowled the advancing Jordan Silk, the Sixers slipped further to 49-4.
Henriques and Carter rotated the strike well in response and while no boundaries came off the bat between overs 10 and 15, the pair provided a solid platform for a final assault.
Together they scored 94 off the last 10 overs, 63 of which came off the final five, with some strong shots down the ground ??? Henriques reaching his fifty off 46 deliveries.
The first maximum of the innings only came in the penultimate over when Henriques lofted Andrew Tye over long on. The captain struck another in the final over bowled by Yasir Arafat before he was run out off the last ball of the innings, attempting an unlikely second run.
Lee conceded just a single off the opening over of the chase and runs continued to prove hard to come by as Shaun Marsh, who struck an unbeaten 63 in last year???s final, and Klinger sought to establish a platform.
After five overs the pair were behind the required run-rate despite pillaging 16 off one Nathan Lyon over and so it continued as the fifty stand came up off 7.1 overs.
The partnership improved to 70 off 11.3 overs before Lee finally made the breakthrough with a slower ball that Klinger (33 off 37) lofted to Abbott at deep square leg.
Marsh (73 off 59 balls) reached his fifty off 48 balls but with 44 runs needed off 24 balls Voges (20) had to go on the offensive and skied a catch just behind square off Doug Bollinger.
The wicket brought Michael Carberry in with 35 needed off 20 balls and with the pressure building wickets continued to fall, Lyon claiming two scalps in the 18th over as Marsh was caught at midwicket and Ashton Turner also picked out Abbott at deep midwicket.
Coulter-Nile swung his second ball away for six to leave the Scorchers needing eight off the final over and the game seemed up when Carberry audaciously flicked the first ball from Lee from outside off-stump over fine leg for four.
The Hampshire batsman picked up three more runs off the next two balls but just when the game seemed up, Lee stepped in to create a grandstand finish.