Chile international Sanchez, who has scored 18 goals already in an impressive debut campaign, faces a late fitness test on a hamstring strain which forced him to miss last weekend’s 5-0 demolition of Aston Villa.
Theo Walcott, who is set to make his 200th Premier League appearance at Spurs, bagged his second goal in as many games against Villa, as did German playmaker Mesut Ozil, which gives Wenger plenty of options as he prepares for a 45th north London derby and a 700th Premier League match in charge.
“For me, the challenge is to find the balance between creative players and the real strikers,” said Wenger, whose side have won just once across north London in six attempts with Tomas Rosicky’s early goal settling matters last March.
“We had too many players because think of who was available (before). Now (Lukas) Podolski is out on loan, so is (Yaya) Sanogo and (Joel) Campbell, and still we do not have (Alex) Oxlade-Chamberlain (who is injured).
“So you could see that at the start of the season, I had even more offensive power.
“All the teams at the top have great offensive power – (Manchester) City, Chelsea, Liverpool, (Manchester) United.
“Getting that one player right gives you the efficiency, and it is not always a player who makes headlines, someone glamorous, most of the time it is a player who works in the dark and who has a real team attitude.”
Wenger is keen to tie up England forward Walcott to another long-term deal, with his current contract entering into the last 18 months.
“Just before he was injured, he was the best Theo I have ever seen,” the Arsenal boss added.
“He had a good balance between being physical, using his pace, and the quality of his finishing had improved tremendously.
“Theo had a lot of injuries. I think what he needs is to be a long time without injury.
“He is 26 in March and now that is (a) decisive (period) for his career, (from) 25 to 30.”