Arsene Wenger???s men were gunned down by a Harry Kane double at Tottenham on Saturday but have the perfect opportunity to respond at home to the Foxes.
The Gunners, who are two points adrift from fourth place, are unbeaten in 21 home matches in all competitions against a Leicester side who find themselves bottom of the league.
Nigel Pearson???s side, who drew 2-2 earlier in the campaign with Arsenal, lost to Crystal at the weekend, stretching a run of 17 Premier League games without a win against London clubs.
Leicester face a difficult task of ending that run in north London having won none of their last 18 matches in all competitions against an Arsenalside with an impressive recent home record..
Arsenal forward Alexis Sanchez is expected to return from a hamstring problem for the clash.
Midfielder Alex Oxlade-Chamberlain (groin) is still out.
England international Jack Wilshere is scheduled to resume training following ankle surgery, while Mikel Arterta (ankle), Abou Diaby (calf) and Mathieu Debuchy (shoulder) continue their rehabilitation.
Robert Huth is in the Leicester squad and could make his Foxes debut.
The defender, on loan from Stoke, has completed a two-game suspension after being banned by the Football Association for breaching its social media regulations.
Goalkeeper Kasper Schmeichel (broken foot) remains an absentee and Chris Wood is still struggling with an ankle injury for the rock-bottom Foxes.