With the Kings 1-0 down after the first 20 minutes, Jeff Carter, Tyler Toffol and Dustin Brown turned the clash around before Carter made it 4-1 with his second goal in the final period to round off the victory.
Los Angeles are now poised to snatch a wild card place in the Western Conference, while Colorado have fallen further off the pace.
Andrew Hammond had a stunning debut in goal for the Ottawa Senators, making 42 saves as they edged Eastern Conference leaders Montreal Canadiens 4-2.
The Canadiens were always playing catch-up after Milan Michalek’s second period strike opened the scoring, with Jean-Gabriel Pageau, Mark Stone and Kyle Turris also on target for Ottawa, while Max Pacioretty and Nathan Beaulieu notched for Montreal.
The Canadiens remain top of the Eastern Conference standings despite the defeat, while Ottawa have work to do if they are going to put themselves into the wild card picture.
The Detroit Red Wings edged a cross-conference battle of two high flyers, with Jimmy Howard decisively saving from Patrick Sharp in the shootout as they beat the Chicago Blackhawks 3-2.
Chicago twice pegged the Red Wings back in the second and third periods, before the shootout heroics of Howard.
Elsewhere, the Minnesota Wild won 3-2 on the road at the Calgary Flames, the Edmonton Oilers claimed a 4-3 shootout win over the Boston Bruins and the Tampa Bay Lightning thumped the Anaheim Ducks 4-1.