Diame was expected to feature for the first time this year but sits out having hurt his knee in training, meaning the Tigers could field the same XI that started last week’s 2-0 win over Aston Villa.
James Chester (shoulder), Liam Rosenior (hamstring) and Robert Snodgrass (knee) remain long-term injuries.
QPR welcome back top goalscorer Charlie Austin for their trip to fellow Premier League strugglers Hull on Saturday.
The 13-goal striker missed the 2-0 win at Sunderland with a foot injury but manager Chris Ramsey has said Austin is back in contention after returning to training.
Mauricio Isla is the latest Rangers player to be sidelined with an injured knee and joins Leroy Fer, Sandro, Richard Dunne and Alejandro Faurlin as players who will miss out through different knee problems, whilst Nedum Onuoha has a hamstring injury.