Mikel has a knee injury and is at least two weeks away from full fitness, so misses the Stamford Bridge clash.
Boss Jose Mourinho has otherwise reported a clean bill of health with no fresh injuries arising from the 1-1 draw with PSG.
Burnley welcome Stephen Ward back into the squad for the first time in two and a half months.
The full-back has recovered from a fractured ankle suffered in the 1-1 draw against Newcastle at the start of December.
Dean Marney has undergone successful surgery on his cruciate ligament injury but will be out until next season along with Kevin Long while Matt Taylor suffered a slight setback in his recovery from Achilles surgery but is back training with the squad again.