The pair returned to training on Friday after suffering an adductor injury and fractured ribs respectively and manager Ronald Koeman is confident they will be fit enough to be involved at St Mary’s.
Left-back Matt Targett is back in contention after a head injury, although Toby Alderweireld, Jay Rodriguez, Emmanuel Mayuka and Ryan Bertrand are out.
Liverpool forward Raheem Sterling is pushing for a start at Southampton after his successful return from injury in midweek.
The England international made his first appearance in three matches after a foot injury as a second-half substitute in the Europa League win over Besiktas.
Captain Steven Gerrard misses out again with a hamstring injury.