The 16-goal striker suffered a knock in a tackle with Lee Cattermole in Saturday’s 0-0 draw at Sunderland.
James Morrison (hamstring) is also a doubt for Tony Pulis’ side along with Victor Anichebe (groin) but the striker could make the bench.
Sadio Mane could start Southampton’s Premier League clash at West Brom on Saturday after being punished for his poor timekeeping.
Manager Ronald Koeman dropped the Senegal winger to the bench for last Sunday’s loss to Liverpool.
Toby Alderweireld (hamstring) is nearing a return and could come back into contention for next Tuesday’s match with Crystal Palace, but Jay Rodriguez (knee) and Emmanuel Mayuka (groin) remain out.