Ireland is set for two to three weeks on the sidelines due to the calf injury he sustained as a result of a controversial Maynor Figueroa tackle in the 1-0 win over Hull on Saturday.
Defender and skipper Ryan Shawcross (back) remains unavailable.
Everton defender Leighton Baines faces a late fitness test ahead of the trip.
The England international has missed the last two matches with a thigh injury and will be assessed to see whether he is ready to return.
Midfielder Christian Atsu, who missed Sunday’s defeat at Arsenal with a virus, will not resume training until Friday.