Having lost to Chelsea in the Capital One Cup final on Sunday, just three days after crashing out of the Europa League at the hands of Fiorentina, it remains to be seen if Pochettino will make changes as Spurs return to Premier League action.
With none of his first-team squad currently out of action, the likes of Roberto Soldado, Erik Lamela and Mousa Dembele will all hoping for a recall having been named on the bench at Wembley.
Swansea playmaker Gylfi Sigurdsson has recovered from hamstring trouble and is in line to start against his former club.
Sigurdsson sat out the 1-0 victory over Burnley on Saturday and should return in the number 10 role behind Bafetimbi Gomis with Jonjo Shelvey deployed in a deeper role for the Barclays Premier League clash.
Kyle Naughton also returns to White Hart Lane for the first time since his January move to Swansea but loan signing Tom Carroll is unable to play against his parent club and drops out of Garry Monk’s matchday squad.