Midfielder Flamini is back in contention after a hamstring problem.
Club captain Mikel Arteta (ankle) is set to step up his rehabilitation, as is defender Gabriel (hamstring), but Jack Wilshere (ankle) is still a few weeks away from a return.
West Ham are without James Tomkins after the defender dislocated his shoulder in training.
The Hammers could also be without three of their first-team strikers. Carlton Cole (hamstring) and Andy Carroll (knee) are definite absentees whilst Enner Valencia is struggling to be fit having suffered a severe cut to his toe after standing on a broken teacup.
Winston Reid will miss out with a hamstring complaint, on-loan Carl Jenkinson cannot feature against his parent club and Alex Song (knee) could also be sidelined – although fellow midfielder Morgan Amalfitano is back having served a three-match ban. Sixteen-year-old defender Reece Oxford could be included in the squad as cover.