The Blues boss insists “everyone wants to play” and has Nemanja Matic available for domestic duty after a two-match suspension was served prior to the European exit to Paris Saint-Germain.
John Obi Mikel (knee) is the only definite injury absentee for the contest.
Toby Alderweireld is set to make his first appearance in nine weeks for Southampton.
The Belgium defender has been out since picking up a hamstring complaint at Manchester United on January 11 and after been an unused substitute last time out, is likely to start at Stamford Bridge.
Jay Rodriguez (knee) and Emmanuel Mayuka (groin) remain absent, but Ronald Koeman has no fresh injury concerns.