England midfielder James Milner (knee) is also set to miss out and left-back Aleksandar Kolarov is doubtful with a muscle problem.
Left-back Gael Clichy is available again after being suspended for the Champions League defeat at Barcelona while fellow defenders Pablo Zabaleta and Eliaquim Mangala have recovered from minor injuries.
Midfielder Chris Brunt is banned for West Brom after accepting a Football Association charge for verbally abusing a match official.
Claudio Yacob is also suspended as he serves the final game of a ban following his red card in the FA Cup defeat at Aston Villa.
Ben Foster is out for at least a month with a knee injury suffered in the 1-0 win against Stoke last week, Brown Ideye and Saido Berahino continue to carry knocks but Victor Anichebe could return from a groin injury.