Upson limped off in their 4-3 defeat to Tottenham before the international break with an Achilles problem and will not be risked.
Dean Hammond (calf) is out and Jeff Schlupp will be assessed after he played in Ghana’s 1-1 draw with Mali on Tuesday with boss Nigel Pearson admitting the winger is tired, while Liam Moore has returned from a loan at Brentford.
West Ham will welcome Winston Reid back from injury for Saturday’s Premier League trip to bottom side Leicester.
The New Zealand defender has been struggling with a hamstring problem but worked on his fitness over the international break and is now in contention to face the Foxes.
Hammers’ boss Sam Allardyce believes the game will come too soon for Enner Valencia (toe) but the Ecuadorian is back in training whilst Andy Carroll (knee), James Tomkins (shoulder) and Doneil Henry (hamstring) all miss out.