Left-back Luke Shaw has recovered from a hamstring problem, but centre-back Chris Smalling is a big doubt due to illness.
Defender Jonny Evans sits out the fourth match of his six-game ban for spitting at Newcastle striker Papiss Cisse.
Ron Vlaar could return for Aston Villa after finally shaking off a calf injury.
The defender has been out since February and will be joined in the squad by Joe Cole after a hamstring issue, while Jores Okore (knee) is also fit.
Kieran Richardson and Philippe Senderos (both calf) are in training but could still miss out while there are doubts surrounding Aly Cissokho (groin) and Nathan Baker (knee) and United loanee Tom Cleverley is ineligible.