Strikers Marouane Chamakh and Fraizer Campbell are both out with hamstring injuries, while midfielder Jordon Mutch remains sidelined with a thigh strain.
Eagles captain Mile Jedinak is also unavailable as he serves the last of a four-match suspension.
Manchester City have no serious injury concerns ahead of the game.
Key midfielder Yaya Toure missed the victory over West Brom a fortnight ago with an Achilles injury but has since played twice for Ivory Coast and is fit.
Fellow midfielder James Milner has also been troubled by a knee injury in recent weeks but the suggestions from manager Manuel Pellegrini are that the England international will be available.