Clattenburg has shown red cards to United???s Luke Shaw and Tyler Blackett, plus City captain Vincent Kompany.
Shaw was sent off late in the 1-1 draw with West Ham while Blackett was dismissed in the 5-3 defeat to Leicester. They are the only red cards Clattenburg has shown in this Premier League season.
Clattenburg officiated Belgium???s 1-0 win over Israel and sent off Kompany after two yellow-card offences.
Clattenburg has shown 78 yellow cards this season, the eighth-highest number shown by a referee in the Premier League in 2014-15.
The 40-year-old has taken charge of four Manchester City fixtures this season: the win over West Brom, draws with Chelsea and Arsenal, and the defeat at Liverpool.
Clattenburg will be joined on Sunday by assistants Simon Beck and Jake Collin, while Jonathan Moss will be fourth official.
The result of the game is crucial for both clubs. For United, it is a chance to cement their place in the top four and continue the late-season form that has put them in the frame for Champions League football next term.
For City, the derby presents a chance to rebound from the hugely disappointing 2-1 defeat to Crystal Palace on Monday. Kompany said it is a “good moment” for the derby despite United heading to Old Trafford as narrow favourites.
“I guess the momentum is a little bit with our neighbours at the moment but it’s the perfect place for us to go and try to rectify what we’ve had,” Kompany said.