Colin Kaepernick has been placed on season-ending injured reserve, possibly signalling an end to his time with the San Francisco 49ers.
Kaepernick began the week, coming off the team's bye, with a shoulder issue he brought to the attention of the medical staff and received treatment for, but he was listed as a full participant in practice.
He was listed as probable on Friday to be available if needed for Sunday's in Seattle as the backup to promoted starter Blaine Gabbert.
But after the team submitted the injury report, Kaepernick returned to the training staff Friday after practice and said the shoulder wasn't making any progress and asked about his options. Surgery is a possibility.
Undrafted rookie quarterback Dylan Thompson was promoted from San Francisco's practice squad Saturday to replace Kaepernick on the active roster.
Kaepernick signed a six-year, $114m (£75m) contract with the 49ers with a $12.3m (£8.1m) signing bonus prior to the 2014 season but the team can cut him without a significant salary cap hit if they so choose.
The 28-year-old's $11.9m (£7.85m) 2016 contract would become fully guaranteed for injury if he's still on the roster on April 1.
He can also earn a roster bonus of $2m (£1.3m) and a workout bonus of $400,000 (£263,000) and the 49ers are highly unlikely to commit that much money to a player they deemed not good enough to start for them in 2015.
Kaepernick completed 59 per cent of his passes this season for 1,615 yards, six touchdowns and five interceptions in eight games. His 78.5 passer rating is the fifth lowest in the NFL among qualified quarterbacks.