LeBron James added 21 points with nine rebounds and eight assists, while Kevin Love added 16 points and 11 boards.
The win leaves Cleveland five games clear of the Chicago Bulls, who lost 105-103 to the Orlando Magic, with Victor Oladipo scoring the winning lay-up for the Magic with 1.5 seconds left.
That took Oladipo on to 23 points for the game as Orlando spoiled the return of Derrick Rose for Chicago.
Rose, playing for the first time in over a month after knee surgery, scored nine points in 19 minutes.
The San Antonio Spurs beat the Houston Rockets 110-98 to record a ninth straight victory behind 27 points from Tony Parker.
The win leaves the Spurs half a game back in the three-way fight for the Southwest Division, with Houston and Memphis just ahead of them in the standings.
The Grizzles stayed ahead with a 110-74 rout of the New Orleans Pelicans, with Zach Randolph collecting 15 points, 13 rebounds and six assists.
The Washington Wizards also enjoyed a blow-out win as they beat the Philadelphia 76ers 119-90, despite the absence of the rested John Wall, who sat out a game for the first time in 208 contests.
Seeking home advantage for the play-offs, the win sees Washington remain one game behind fourth-placed Toronto in the Eastern Conference, with the Raptors beating the Charlotte Hornets 92-74 behind 18 points from DeMar DeRozan.
A season-high 34 points from Isaiah Thomas helped the Boston Celtics to a 113-103 win over the Detroit Pistons, knocking Detroit out of the play-off picture.
The Indiana Pacers kept their own bid alive with a 102-86 win over the New York Knicks, tying them with the Miami Heat, one game off the final-play-off spot behind Boston and the Brooklyn Nets.
Brooklyn lost 114-111 to the Atlanta Hawks.
The Phoenix Suns are out of the play-off frame after a 107-104 loss to the Dallas Mavericks.
LaMarcus Aldridge needed only the first three quarters to amass 24 points and 13 rebounds as Northwest Division title winners Portland beat the Minnesota Timberwolves 116-91.
Kenneth Faried’s 29 points and 11 rebounds helped the Denver Nuggets beat the Los Angeles Lakers 119-101 and Derrick Favors had 18 points, 11 rebounds and three blocks as the Utah Jazz beat the Sacramento Kings 103-91.