Khan has been trying to arrange a clash with Mayweather for the last few years but all to no avail.
The 38-year-old from Michigan, who has won all 47 of his professional bouts to date, will next step into the ring on May 2 when he takes on Filipino superstar Manny Pacquiao in one of the most anticipated bouts in boxing history.
Hatton thinks Mayweather will come out on top when the duo clash at MGM Grand Garden Arena next month and the former world welterweight and light-welterweight champion believes Khan could cause problems for ???Pretty Boy.???
Hatton said: “I think Floyd would run a mile from Amir Khan not because of a fear factor, but because styles make fights.
“Amir is boxing with a lot more discipline lately. He’s in and out and he’s not getting involved. I think that type of style will cause Floyd massive problems.
“But, when you’re the best, pound-for-pound, like Floyd Mayweather ??? and Amir’s as big a name as is out there, and he’s beaten pretty much everyone ??? he might be forced to fight Amir Khan.
“He might be running out of opponents. I say this all the time, and everybody laughs at me: I think he’s got a good chance of beating him.”
As for the Mayweather-Pacquiao clash, which will unify three world welterweight titles, Hatton added: “Although I think Manny’s got the style to beat him, I’m still going to go with Mayweather.
“He always finds a way to win. He’s a very, very clever fighter, Manny, but you’d have to say the cleverest fighter in boxing is Mayweather.”