The defending champions, unbeaten at home last season, closed on 128 for three, still 158 from their safety target of 286.
In a hard-fought encounter, Ian Westwood was the stand-out player during Warwickshire’s marathon knock which lasted for 143.3 overs.
Westwood, 151 not out overnight, looked all set for a faultless double century until he fell lbw to off-spinner, James Middlebrook, for a career-best 196 from 377 balls with 25 boundaries.
John Hastings dug Durham out of a hole with the bat on the second day of their match against Sussex, who moved on to 115 for three at stumps in their second innings after the hosts were earlier dismissed for 339.
Going in at number 10 for Durham when three wickets had fallen on 222, Hastings made 72 to earn a first-innings lead of four runs, sharing a ninth-wicket partnership of 116 with Usman Arshad.
Matt Machan had reached 29 not out at the close for Sussex, who lost the wickets of Chris Nash, Ed Joyce and Craig Cachopa, with Harry Finch unbeaten on nine.
Nottinghamshire fast bowler Luke Wood claimed two scalps to keep the visitors on top against Hampshire at the Ageas Bowl.
Wood kept Hampshire under the cosh, with the home side trailing by 204 runs on 167 for four, replying to 371 all out.
Jimmy Adams’ 61 was a rare positive for a Hampshire side who are continuing to adjust to life back in Division One.
Nick Gubbins and Adam Voges were both dismissed in the 90s as Middlesex replied to Somerset’s 408 with 306 for seven on a rain-hit second day against Somerset at Taunton.
Gubbins was three short of his highest first-class score of 95 when Jamie Overton had him taken at second slip by Marcus Trescothick.
Skipper Voges was two short of his first century for Middlesex when he fell lbw to Lewis Gregory, who also accounted for Sam Robson, Nick Compton and Neil Dexter in a return of four for 93 from 21 overs. Fellow youngster Overton also bowled impressively to take three for 42 in 11 overs.
Lancashire’s Alex Davies fell one short of a maiden first-class century and Kyle Jarvis took three for 35 as the Red Rose dominated the second day of their Division Two game against Kent at Emirates Old Trafford.
By the time rain ended play eight overs early, Rob Key’s team were 214 for seven, still 230 runs in arrears of Lancashire first-innings 444 and the visitors’ main hope of scoring the 81 runs they need to avoid the follow-on seems to rest with Sam Northeast, who is 48 not out.
Opener Nick Browne scored a career-best 143 to lead Essex to a challenging 266 for two as they responded to Surrey’s first-innings 340 on day two at the Kia Oval.
Browne shared a rousing opening partnership of 155 with Jaik Mickleburgh (61) and added another 109 in company with Daniel Lawrence (48 not out).
It made it a chastening day for Surrey, who had started the second day on 293 for five but collapsed once Steve Davies was out for 81 and lost their last four wickets for no runs in 13 balls.
Northamptonshire’s seamers took five wickets in the second hour of play to bowl the visitors back into a match against Leicestershire at Grace Road.
The hosts lost five wickets for just 37 runs, and were grateful to Clint McKay and Ben Raine, who stuck around long enough to give them a first innings lead before they were bowled out for 305. However, Northamptonshire had time to put on 105 for two before stumps for a lead of 51.
Martin Guptill blasted a sensational maiden first class double century to put Derbyshire in a winning position on the second day against Gloucestershire at Bristol.
The 28-year-old New Zealander hit 227 off just 176 balls, with 29 fours and 11 sixes, reaching his double hundred with three successive maximums off Liam Norwell as his side ran up 511 for eight in reply to the home side’s 275.