The Foxes boss is ready to delay the leaders’ title charge and aid his own side’s relegation fight.
They are a point above the Barclays Premier League drop zone having won their last four games.
Cambiasso played under Mourinho at Inter Milan, winning the Champions League in 2010, and has been a key player for the Foxes since moving from the San Siro last summer.
And as Leicester plot a fifth straight win Pearson believes the former Argentina international has special know-how of Mourinho.
“I would say it is very probable he will,” he said.
“It will be discussed, of course it will. The bottom line is we come up against a side who are very accomplished, who have a lot of talent in there and are in the driving seat in terms of league position.
“We have to make sure we approach the game to give ourselves the best chance of winning it. To do that we have to be at our best knowing they have an awful lot of experience on the pitch and off the pitch in the dugout, on the touchline.”
Chelsea will win the title by beating the Foxes and then Crystal Palace on Sunday following their 0-0 draw at Arsenal, which saw Gunners fans label Mourinho’s men boring.
But Pearson believes Chelsea are winners and would deserve the league crown.
“Any side that wins the league wins it with the players they have got and they are an exceptional side,” he said.
“Winning trophies is important and how you do it, you do it by playing a brand of football that people like or a brand of football that some people don’t like, but if you ask the Chelsea fans I bet they like it. It is winning football.
“Any team that wins the Premier League are worthy champions. That speaks for itself, any side that wins it are worthy champions.”
Pearson could be without David Nugent and Jeff Schlupp who are struggling with calf injuries while Jamie Vardy will be assessed as he battles a foot problem.
The forward needed an injection in his foot before scoring in Saturday’s 1-0 victory at Burnley and Pearson is unsure if the 28-year-old will be able to manage the issue until the end of the season.
He said: “I don’t know, it’s more discomfort. Injections are not the ideal answer but is a painkilling injection. The potential problem of that type of treatment is when you are playing and you’re unaware of what potential damage you are doing.
“We don’t take these decisions lightly. If we felt there was a greater risk of something more serious happening there wouldn’t even be a decision to make for the player, I would take it out of his hands alongside our medical staff.”