The Frenchman has sat out the last two games following his second dismissal of the season at Liverpool at Liverpool on April 13, and his presence in the squad could hardly be more timely with the Magpies having lost each of their last seven games.
Sissoko could be joined by defender Paul Dummett following his recovery from a knee problem, while midfielder Siem de Jong, who scored on his return as a substitute against Swansea last weekend after an eight-month lay-off, got 90 minutes under his belt for the club’s Under-21s on Tuesday.
Hosts Leicester are sweating on injuries to Robert Huth and Andy King.
The pair limped off in Wednesday’s 3-1 defeat to Chelsea with King nursing a hamstring problem and Huth hurting his calf.
Both have had scans and will be assessed but David Nugent is out with his own calf problem, although Jeff Schlupp returns following another calf issue.
Kick-off at the King Power Stadium is 12:45pm.