Defenders Luke Shaw (groin), Marco Rojo (adductor), Jonny Evans (nerve) and Rafael (rib) are out, as is central midfielder Michael Carrick (calf).
Centre-half Phil Jones has resumed training following his ankle injury but is unlikely to feature as he lacks match fitness.
Head coach Tony Pulis remained tight-lipped about West Brom’s injuries but admitted the Baggies had several knocks for the trip to Old Trafford.
Youssouf Mulumbu is back from suspension though having sat out the last three games following a red card against QPR last month.
James Morrison could be a doubt after coming off late on in last week’s 0-0 draw against Liverpool with a knock to the head and a bad back while Ben Foster (knee) remains a long-term absentee.