The Yorkshire opener appears almost certain to play in the first Test against New Zealand next Thursday after being named as one of two uncapped players in a 12-man squad, along with Durham pace bowler Mark Wood.
Lyth went on the tour of the West Indies but was overlooked as a possible partner for captain Alastair Cook, with Jonathan Trott preferred to the 27-year-old.
But Trott has since retired from international cricket, leaving a gaping hole at the top of the England order that Lyth would love to fill in the long-term.
He told Sky Sports News HQ: “I???m over the moon after getting the phone call, and it looks like I am going to be opening the batting next Thursday which I am delighted to be doing.
“I???m very excited. I am sure there are going to be some nerves come next week, on the Wednesday night, but I am just looking forward to the challenge ahead and walking out there with Alastair Cook.
“It will be one of the proudest moments of my life.
“It was great to get the experience and great to be on that (Caribbean) trip. Obviously I was a bit disappointed I didn???t play but now I get my chance at Lord???s and there is no better to place to make a debut.
“I???m looking forward to getting down there and hopefully getting some runs in front of a packed house at Lord???s, which would be great.
“I???ll take one game at a time, and it will be a challenge against a very good New Zealand side, but hopefully I???ll be in the side for a long period. Obviously I???d love to play in an Ashes series as well, and that is in the back of my mind.”