Vice-captain Michael Carrick (calf), defender Luke Shaw (head), and midfielder Andreas Pereira (international duty) are unavailable while centre-back Jonny Evans is a doubt with an unspecified injury.
Right-back Rafael is unlikely to play despite overcoming a rib injury. Defender Marcos Rojo (adductor), striker Robin van Persie and midfielder Angel di Maria (both illness) are available after overcoming their respective problems.
Arsenal forward Danny Welbeck will miss the return to former club Manchester United on Sunday because of a knee injury.
Midfielder Aaron Ramsey, who has been carrying a leg problem, is expected to feature having resumed training again following Monday night’s home defeat by Swansea.
Captain Mikel Arteta (ankle), midfielder Alex Oxlade-Chamberlain and full-back Mathieu Debuchy (both hamstring) are still not match fit.