The Tigers suspended midfielder Jake Livermore for failing a drugs test on Friday and were beaten 2-0 at Tottenham on Saturday, a defeat which puts the club on the brink of Premier League relegation.
Hull can stay up on the final day if they beat Manchester United and Newcastle and Sunderland both lose; a Newcastle draw would see them safe but only if United are beaten by more than seven goals at the KC Stadium.
Relegation looks a very real possibility for Bruce, who admitted the past day has been the low point of his managerial career.
???It???s unquestionably been the hardest 24, 36 hours that I???ve ever had in football management,??? he said. ???Sometimes it???s difficult to get your head around things.
???You just have to get on with it and not let it affect anybody. Top to bottom, all of us are hugely disappointed with what the outcome has been but we have to move on.
???We have to dust ourselves down and we prepared as best we could. It was a top-class performance from us.???
Newcastle???s final game is against West Ham at St James??? Park, a fixture which ??? theoretically ??? looks a lot more straightforward than Hull???s against Bruce???s former club.
But Bruce is confident his players can achieve an unlikely win over the Red Devils and remain in the Premier League.
???We have to believe that we can beat Manchester United next weekend, which is always going to be difficult,??? he said.
???The players were terrific and I couldn???t fault them to a man. Six or seven of them got me into this league a couple of years ago so I know what they???re capable of producing.
???We???re not in this situation for the performance today but we???ve still got a really good chance. It will be a tall order to beat Manchester United but we???re confident we can.
???There might be one final twist. Can we upset the apple cart and produce a performance? If we do that we???ll put pressure on the other teams.???
As far as the defeat at Spurs was concerned, Bruce was in no doubt about the root cause of it ??? a failure to take the good goalscoring chances which came his side???s way.
Nikica Jelavic hit the bar for the Tigers in the first half, but while Tottenham???s chances were few and far between, they did not waste them.
???We played so well it was scary, we created the better chances and we were the better team. If we???re being honest with each other that???s the problem,??? he said.
???You can???t come to somewhere like Tottenham and have five or six really good chances and not take them.
???We???ve created enough but we???ve switched off at the back and made some silly errors. We???ve been punished ??? they had two chances and they took them.
???If we???d have played like that last week then we might not be in this situation. We might still have needed a result to go our way but we???d have been better off.???