Chicago captain Jonathan Toews scored two early goals and the Blackhawks stunned Anaheim by surging into a 4-0 lead in the second period before the Ducks got on the scoreboard.
Brandon Saad, Marian Hossa and Brent Seabrook also netted for Chicago, while Ryan Kesler, Corey Perry and Matt Beleskey replied for the Ducks.
Kesler reduced the deficit to 4-1 late in the second period and Perry gave Anaheim some hope with 8:24 remaining, but Seabrook???s strike shortly afterwards sealed the victory.
With the road win in southern California, the Blackhawks won the series 4-3 and will meet the Tampa Bay Lightning in the Finals, which start on Wednesday.
It is the third season in a row that Anaheim have lost Game Seven of a play-off series at home.
The Blackhawks won the Stanley Cup in 2010 and 2013 and have built up some serious momentum after winning the final two games against Anaheim.
The result was a bitter pill for the Ducks, who gave up a goal after barely two minutes.
Defenseman Niklas Hjalmarsson fired a shot that rebounded off Anaheim goalie Frederik Andersen, and Toews pounced to score.
The team scoring first had won the first six games of the series, and Game Seven proved no different.
Toews, who has scored five goals in his past four games, paid tribute to Blackhawks coach Joel Quenneville after the win.
“The last couple of games, Joel did a great job analysing the situation and how we can try and take their top players off their game,” Toews said.
“They were having a heck of a series. We just went out and tried to make it difficult on that line. They wanted to play offense and for the most part we were pretty smart defensively against them.”