Wales are sweating over the fitness of fly-half Dan Biggar and wing George North for Saturday’s clash with England in Cardiff after they sustained knocks in Sunday's win over Italy.
Biggar was replaced at half-time due to an injury to his ribs and North hurt his thigh early on in Rome but managed to finish the game.
"Dan has taken a bump to his ribs but we will wait for more medical information on that," Wales caretaker coach Rob Howley told Press Association Sport.
"George took an early bump and has a haematoma on his thigh. I am delighted he stayed on. I thought he showed some mental toughness, which is important in games when you come away from home."
Taulupe Faletau (back-row) and Luke Charteris (lock) missed the clash against Italy through injury and their fitness situation will be reassessed when Wales reconvene on Tuesday.
Wales fought back from a 7-3 half-time deficit in Rome to claim a 33-7 victory after North, fellow wing Liam Williams and centre Jonathan Davies scored tries and full-back Leigh Halfpenny contributed 18 points via three conversions and four penalties.
"It is important we start competitions well," added Howley.
"We haven't done so since four years ago, really. We can go into the next game with a bit more self-belief and confidence.
"We want to improve in all areas. We will have to put England under more pressure than we did against Italy, so that is going to be the challenge."