It is "highly unlikely" that Eben Etzebeth will be fit to face Wales on Saturday in South Africa's final Test of their November tour.
The lock suffered concussion against England at Twickenham and has not recovered quick enough to be considered for the game against Wales.
"It is highly unlikely he would be ready for this weekend‚" Springbok coach Allister Coetzee said on Monday.
"Eben didn’t pass his protocols on Sunday‚ that makes it unlikely. If he passed the five-day return-to-play protocol (on Monday) he would only be ready to take contact on Saturday‚ so that makes it highly unlikely."
Coetzee also confirmed that there were no other major injury concerns and the rest of the squad was fit and available for selection.
The Boks didn't have any training on Monday with heavy rain in Cardiff.
"We want to ensure the players have time to put the disappointment of the Italy result behind them. I want there to be enthusiasm on Saturday and for us to put in a good performance," Coetzee explained.
The under-fire Bok coach also confirmed he will be looking to give other players a chance against Wales.
"My philosophy for the game against Italy was to keep continuity after our Test against England and win. We didn't, so I have to give other players an opportunity.
"There is a plan for the way forward and we have to see if the younger players can cope at this level. There are players who have worked ahrd and deserve a chane."