Ireland duo Sean O'Brien and Peter O'Mahony are poised to start against Canada on Saturday after missing the historic win over New Zealand.
The pair, who say they were ready to play in Chicago, are likely to be part of many changes made by head coach Joe Schmidt for the match.
Both played for their respective province last weekend to gain minutes and after being on media duty on Tuesday, they should be in the XV.
"I think it was good that we didn’t take them to Chicago to play against New Zealand, for a number of reasons,” Ireland assistant coach Simon Easterby told the42.ie as they look to build on last week's fine victory.
"They’ve both come back from long-term injuries and I think it’s kind of a little bit of a risk sometimes to feel that you’ve got to go out and pick a team for a certain game.
"Both of them got game time at the weekend, got more time under their belt and I think that will only serve them well in terms of their preparation."
Easterby added: "The good thing for us, I feel, is that those guys coming back in – not just Seanie and Pete, but everyone coming back in – if they get the opportunity they want to make a mark this weekend and prepare themselves really well for the Test game."