Matt Kemp completed the first cycle in San Diego Padres history on Friday as he lead his side to a 9-5 win over the Colorado Rockies.
Kemp, who drove in four RBIs, secured the cycle with a ninth-inning triple off Justin Miller having homered in the first, hit a single in the third and launching a go-ahead double in the seventh inning.
Jedd Gyorko smashed a three-run homer in a crucial four-run sixth inning for Padres after the game was tied 4-4 after Brandon Barnes a RBI tripled in the fifth.
Elsewhere, Gregory Polanco's RBI single and Aramis Ramirez's sacrifice fly in the 10th inning helped the Pittsburgh Pirates end the New York Mets' four-game winning streak with a 3-2 win at Citi Field.
Pirates' Neil Walker and Mets' Yoenis Cespedes homered in the first and sixth respectively to tie the game at one-all, where it remain until the 10th.
The visitors drove home the two runs at the top of the tenth, before Mark Melancon grabbed his MLB-leading 36th save in the bottom of the inning.
Over at Fenway Park, the Boston Red Sox served up a 15-1 blowout of the Seattle Mariners, shortly after finding out manager John Farrell has stage one lymphoma.
Farrell announced the news before the game, revealing that he would miss the remainder of the season.
The Sox, though, rallied together and delivered a season-high 21-hit game, Travis Shaw homered twice, while Pablo Sandoval went 3-for-5 with two doubles and three RBIs.
Rusney Castillo smashed a two-run homer before leaving the game with a foot problem, while Kyle Seager hit a solo shot to score the Mariners' only run.
Over at Oriole Park at Camden Yards, Manny Machado slammed a two-run walk-off home run in the 13th inning to give the Baltimore Orioles the 8-6 win in the series opener against the Oakland Athletics.
The A's jumped out to an early 4-0 lead, helped by Stephen Vogt's two-run homer in the fifth inning.
Adam Jones hit a three-run homer to keep the Orioles in the game, before Chris Davis struck a two-run bomb in the eighth to give the Birds a 6-4 lead.
The A's rallied back in the ninth, but Machado's two-run shot in the bottom of the 13th was enough to secure the win.
The Chicago Cubs pushed their winning streak to eight games with a 6-5 win over the Chicago White Sox in the opener of the Crosstown Classic on Friday.
Chris Coghlan homered twice and drove home four runs, before Anthony Rizzo hit the go-ahead solo shot in the fifth to secure the win.
Avisail Garcia and Adam Eaton led the way for the White Sox with two RBIs each in the setback.
The New York Yankees reclaimed first spot in the American League East as they snapped the Toronto Blue Jays' 11-game winning streak with a come-from-behind 4-3 win at Rogers Centre.
The Blue Jays raced into a 3-0 lead in the third, but a four-run eighth inning rally behind Chase Headley's RBI double and Carlos Beltran's three-run blast gave the Yankees the win.
Chicago White Sox 5, Chicago Cubs 6
Baltimore Orioles 8, Oakland Athletics 6
Toronto Blue Jays 3, New York Yankees 4
New Yor Mets 2, Pittsburg Pirates 3
Boston Red Sox 15, Seattle Mariners 1
Atlanta Braves 3, Arizona Diamondbacks 2
Texas Rangers 5, Tampa Bay Rays 3
Minnesota Twins 1, Cleveland Indians 6
Houston Astros 5, Detroit Tigers 1
Kansas City Royals 4, Los Angeles Angels 1
Milwaukee Brewers 3, Philadelphia Phillies 1
St Louis Cardinals 3, Miami Marlins 1
Colorado Rockies 5, San Diego Padres 9
LA Dodgers 5, Cincinnati Reds 3
San Francisco Giants 8, Washington Nationals 5