The Jaguares have made four changes to the side that will face the Lions at Emirates Airline Park on Saturday.
Julián Montoya comes in for suspended captain Agustín Creevy, which sees Facundo Bosch being named as cover for the hooker position.
Scrum-half Martín Landajo takes over the captaincy from Creevy and the former pairs up with Nicolás Sánchez to form the half-back combination.
A hefty ten-week ban for back-rower Leonardo Senatore allows Facundo Isa to be promoted from the bench to the starting XV.
Tomás Lezana replaces Javier Ortega Desio in the number seven position with the latter being demoted to the replacement bench.
Manuel Montero makes way for Lucas González Amorosino on the left wing in the only change in the backline. Juan Martín Hernández and Matías Orlando will continue their pairing in the midfield.
Jaguares: 15 Joaquín Tuculet, 14 Emiliano Boffelli, 13 Matías Orlando, 12 Juan Martín Hernández, 11 Lucas González Amorosino, 10 Nicolás Sánchez, 9 Martín Landajo (c), 8 Facundo Isa, 7 Tomás Lezana, 6 Pablo Matera, 5 Tomás Lavanini, 4 Matías Alemanno, 3 Ramiro Herrera, 2 Julián Montoya, 1 Santiago García Botta.
Replacements: 16 Facundo Bosch, 17 Facundo Gigena, 18 Nahuel Tetaz Chaparro, 19 Guido Petti, 20 Javier Ortega Desio, 21 Gonzalo Bertranou, 22 Santiago González Iglesias, 23 Ramiro Moyano.
Date: Saturday, May 21
Venue: Emirates Airlines Stadium, Johannesburg
Kick-off: 15:00 local (13:00 GMT)
Referee: Stuart Berry
Assistant Referees: Cwengile Jadezweni, Lourens van der Merwe
TMO: Willie Vos