Marshawn Lynch and Brandon Mebane are both questionable for the Seattle Seahawks' Monday Night Football clash against the Detriot Lions.
Running back Lynch has been struggling for match fitness with a niggling hamstring injury, while key defensive figure Mebane has been troubled by a groin problem; leaving question marks over the duo after they sat out the final practice session on Sunday.
Lynch has only been able to rush 128 yards in three games for the Seahawks this season, but head coach Peter Carroll has said the lack of minutes on the field would not stop him starting against Lions if he is able to pass a late fitness test.
"We would go with him if he could make it," Carroll said. "He has had other weeks when he wasn’t able to practice and he played very well, but we’ll have to wait and see.
"We won’t know all the way until game time," Carroll added, who also declared Mebane was facing a similar situation.
As for the Detroit Lions, still awaiting their first win of the season, they will definitely be without running back Joique Bell.
The veteran has been tormented by knee and Achilles injuries and has now picked up an ankle injury which has ruled him out of practice all week.
Rookie Zach Zenner is poised to step up in his absence, and the Lions have given him their backing as he prepares to be heavily involved in their offense.
"Oh, he's ready," Lions offensive coordinator Joe Lombardi said. "Zach, if you guys knew him, you know he's ready. He's going to be just fine, whatever is asked of him.
"If all the running backs wake up on Sunday with the flu, Zach Zenner could do it all."
Tight end Brandon Pettigrew is also missing as he continues his recovery from a hamstring problem.