Tommy O'Donnell comes in at flank for Ireland when they face Scotland in the Six Nations in Dublin on Saturday.
Rory Best will play in his 32nd consecutive Six Nations fixture and will lead a side that sees Jack McGrath and Mike Ross pack down alongside him in the front row.
Donnacha Ryan and Devin Toner continue their second row partnership while O'Donnell comes in at openside with CJ Stander and Jamie Heaslip completing the back row.
Conor Murray and Johnny Sexton line out at nine and ten with Robbie Henshaw and Jared Payne continuing in midfield.
Simon Zebo retains the full-back position and is flanked in by Keith Earls and Andrew Trimble on the left and right wing respectively.
The replacements include Cian Healy and Eoin Reddan both of whom have recovered from injury, while Richardt Strauss is also included.
Ireland: 15 Simon Zebo, 14 Andrew Trimble, 13 Jared Payne, 12 Robbie Henshaw, 11 Keith Earls, 10 Jonathan Sexton, 9 Conor Murray, 8 Jamie Heaslip, 7 Tommy O'Donnell, 6 CJ Stander, 5 Devin Toner, 4 Donnacha Ryan, 3 Mike Ross, 2 Rory Best(c), 1 Jack McGrath
Replacements: 16 Richardt Strauss, 17 Cian Healy, 18 Nathan White, 19 Ultan Dillane, 20 Rhys Ruddock, 21 Eoin Reddan, 22 Ian Madigan, 23 Fergus McFadden
Date: Saturday, March 19
Venue: Aviva Stadium, Dublin
Kick-off: 15:00 GMT
Referee: Pascal Gauzère (France)
Assistant referees: Craig Joubert (South Africa), Alexandre Ruiz (France)
TMO: Shaun Veldsman (South Africa)