The Atlanta Falcons returned to winning ways with a tense 10-7 win over the Tennessee Titans in Nashville.
Matt Ryan threw two interceptions in his worst performance of the season, but a pass from the Falcons quarterback to favourite target Julio Jones proved the difference between the sides.
Tennessee had Zach Mettenbeger at quarterback in place of rookie star Marcus Mariota, and he gave the Titans a second-quarter lead with a 19-yard pass to Kendall Wright.
But that would prove to be their last score of the game, with Mettenberger throwing two costly interceptions as a Matt Bryant field goal and Jones' eight-yard score took the Falcons to 5-1 on the season.
The New Orleans Saints held off a second-half rally from the Indianapolis Colts to claim a 27-21 win at Lucas Oil Stadium.
Khiry Robinson scored two early rushing touchdowns, Drew Brees hooked up with Michael Hoomanawanui for a third and Mark Ingram made it 27-0 early in the third quarter with a one-yard plunge.
Andrew Luck was booed off by Colts fans after a poor first-half but he came alive after the break and connected with T.Y. Hilton for touchdowns from 87 and 46 yards.
Luck found Donte Moncrief in the endzone for an eight-yard score to bring them within six points but the Colts could not force a late turnover and drop to 3-4, albeit good enough to keep the AFC South lead.
There was a massive comeback victory for the Washington Redskins as Kirk Cousins led them to a 31-30 win over the Tampa Bay Buccaneers after they had trailed by 24 points.
Jameis Winston threw two touchdown passes and Howard Jones picked up a fumble recovery for a third Buccaneers score, but they would only muster two more Connor Barth field goals after that.
And that left them vulnerable to an inspired Cousins, who linked up with Ryan Grant and Jordan Reed to cut the deficit in the third quarter.
Six points behind with time ticking down, Cousins and Reed connected for a second touchdown to take a one-point lead, and victory was confirmed when Charles Sims lost a fumble as Tampa Bay drove looking for what would have been a winning field goal.
The Miami Dolphins scored 41 unanswered points in the first-half before beating the Houston Texans 44-26 for their second straight victory.
Ryan Tannehill threw four touchdowns and the Dolphins became the first team in more than 75 years to have four touchdowns of at least 50 yards in a half.
Jarvis Landry scored two touchdowns, as did Lamar Miller who had 236 yards of total offense before being rested in the second half.
And the second-half rally could have come at a cost for the Texans, who appear to have lost star running back Arian Foster to a season-ending Achilles injury. Foster scored two of Houston's four touchdowns with the others going to wide receiver Nate Washington.
Charcandrick West rushed for 110 yards and his first career touchdown as the Kansas City Chiefs (2-5) ended a five-game losing streak by beating the Pittsburgh Steelers 23-13.
Teddy Bridgewater threw a pair of touchdowns – one a spectacular catch by Stefon Diggs – as the Minnesota Vikings beat the Detroit Lions 28-19 at Ford Field.
Diggs went full-length to catch a Bridgewater pass and help the Vikings overcome an 11-point deficit to improve their record to 4-2. The Lions looked superb early in the game, but fell apart after scoring 14 of their points in the first quarter.
Rookie running back Todd Gurley starred for the St Louis Rams in their 24-6 win over the Cleveland Browns.
Gurley rushed for 128 yards on 19 carries and scored two of the Rams' three touchdowns, the other coming on a fumble recovery from Rodney McLeod.