The Arizona Cardinals won their first NFC West division title since 2009 in style as they hammered the Eagles 40-17 in Philadelphia.
David Johnson ran for 187 yards and three touchdowns and Carson Palmer threw a touchdown pass to John Brown as the Cardinals cruised to a comfortable win.
Arizona led 17-10 at halftime, and delivered the knockout blow when safety Deone Bucannon intercepted Eagles quarterback Sam Bradford and ran it in for a touchdown for a 37-10 lead at the start of the fourth quarter.
The Cardinals (12-2) will earn a first-round bye with a win over Green Bay next week. They still have a chance to secure the No 1 seed if they win out and Carolina loses its last two games.
Despite the loss, the Eagles' play-off fate remains in their own hands and they can clinch the NFC East title if they beat Washington at home and the Giants on the road in their final two games.
The Cardinals outclassed Philadelphia in every way on their way to their eighth straight win.
Johnson, a rookie filling in for injured backs Chris Johnson and Andre Ellington, had a pair of one-yard touchdown runs and a 47-yarder.
Palmer gave Cardinals fans a brief scare when he came out for one play after injuring his right index finger on a throw. But he returned to toss a 16-yard touchdown pass to John Brown and finished 20 of 32 for 274 yards.
Bradford finished 28 of 41 for 361 yards with two touchdowns and two interceptions for the Eagles. Jordan Matthews had eight receptions for 159 yards and a score.
Eagles running back DeMarco Murray – who signed a five-year, $40m contract in the offseason as a free agent – continues to be phased out of the offence by Chip Kelly as he had just two carries for three yards.
Murray led the NFL with 1,845 yards rushing for Dallas last season but has just 603 through 14 games in 2015 and his future in Philadelphia appears far from certain.
The 27-year-old admitted he is frustrated after the game but stressed he remains committed to the team.
"I want to play," Murray said. "This is what I signed up for. I'll be here. I signed up to be here for an opportunity to make the play-offs.
"Whenever I get an opportunity I just got to make the best of it," he added. "I'm not calling the plays. Things [that are] out of my control, I can't worry about it."