The 26-year-old Wilmslow man had won their first meeting on points in 2011, but the return bout was a far more one-sided affair with Fury dictating the fight from the opening bell at the ExCel Arena in London.
Fury set the tone with a busy jab in the first round, ramming his favoured weapon through the defences of Chisora. A right hand knocked the Finchley man briefly off balance as he plodded through a cluster of punches.
Brimming with confidence, Fury switched to southpaw in the second, lashing his confused foe with left hands, but Chisora finally answered with a trademark looping hook in the third.
These crude attacks were failing to unsettle Fury, who continued to alter his stance, wobbling Chisora with a left hook in the fourth round. ??
A steady stream of stinging jabs were gradually taking their toll on Chisora as the rounds continued and he sported a badly swollen eye at the end of the fifth.
Fury stuck to his task, showing the discipline that had been lacking in some erratic previous displays. A persistent jab was draining the fight from Chisora in the sixth, while he was clipped with hurtful hooks in the seventh.
A disillusioned ???Del Boy??? did land another desperate right in the eighth, but he could not fend off Fury, who lashed him with left hands in the ninth.
Trainer Don Charles pleaded for one final stand from Chisora in the 10th, but his fighter had nothing left and a spearing jab sent him into retreat. Fury, sensing the finish was near, unloaded a flurry of hooks on his wilting opponent.
At the bell, Chisora was heavily bruised and beaten, reluctantly agreeing with Charles as he waved off the onslaught.
Fury regained the British belt and was also awarded the European strap with the victory, but edges closer to a fight with heavyweight king Wladimir Klitschko after winning the WBO title eliminator.
Paying tribute to his late Uncle, who recently passed away, Fury said: “To be honest, I never took many blows. I’m very proud of my performance, I dedicate it to my Uncle Hughie.
“Wladimir Klitschko, I’m coming for you baby. No retreat, no surrender.”??