Sissoko and Colback missed the midweek draw at Burnley and their return is a welcome boost to Magpies boss Alan Pardew who has a number of injury concerns.
Captain Fabricio Coloccini is unlikely to be risked as he continues to recover from a hamstring injury while Mike Williamson, Daryl Janmaat and Sammy Ameobi all face late fitness tests.
Diego Costa will start Chelsea’s Premier League trip to Newcastle on Saturday after suspension.
The Spain hitman will return for the Blues at St James’ Park even though both Didier Drogba and Loic Remy both found the net in Wednesday’s 3-0 win over Tottenham.
Gary Cahill is fit to face the Magpies despite picking up a head knock against Spurs, with Ramires and John Obi Mikel competing to replace the suspended Nemanja Matic.