Rose has recovered from a rib injury and could replace Ben Davies at left-back, but Vlad Chiriches and Kyle Naughton are both doubtful with knocks.
Emmanuel Adebayor is still recovering from a virus and is not considered ready while Kyle Walker is expected to play for the club’s under-21 team after returning from an abdominal injury.
Crystal Palace are likely to be without midfielder Joe Ledley for their trip to Tottenham on Saturday.
The Wales international is suffering from a recurrence of a hip problem that ruled him out of Tuesday night’s defeat to Aston Villa.
He is unlikely to be fit to return at White Hart Lane and will join defenders Damien Delaney (calf) and Adrian Mariappa (knee) on the sidelines – with Dwight Gayle available having been forced off against Villa through illness.