Spurs made four changes following the Leicester win for the Manchester United draw and can be expected to make a similar number of switches as they bid to end a 10-match winless run against the Blues.
Kyle Walker, Danny Rose, Erik Lamela and Aaron Lennon are among those who could return to the starting XI.
Chelsea manager Jose Mourinho has a full squad to choose from as the Premier League leaders seek to maintain their unbeaten record against Tottenham.
The Blues boss has no injury concerns or suspended players as Chelsea go to White Hart Lane to play against a Spurs side who last beat them in April 2010.
Chelsea could keep changes to a minimum, with Sunday’s FA Cup third-round tie with Watford a more likely opportunity to rotate front-line players out of the starting XI.