The wide man will be out for four to six weeks with a hamstring injury he suffered on New Year’s Day at Stoke.
New goalkeeper Victor Valdes is expected to be in the United squad while Rafael (cheekbone), Luke Shaw (ankle), Marcos Rojo (thigh), Daley Blind (knee), Marouane Fellaini (illness) and Antonio Valencia (groin) have overcome their respective problems.
Nathaniel Clyne and Jack Cork could return for Southampton’s trip to Manchester United, where new signing Eljero Elia is in line for his debut.
Right-back Clyne this week returned to training after an ankle injury and will be assessed before the match, while midfielder Cork is available after an ankle complaint of his own. Elia is in the squad for the first time since joining on loan from Werder Bremen, although Jay Rodriguez (cruciate ligament) and Sam Gallagher (knee) remain absent.
Japan defender Maya Yoshida has left for international duty at the AFC Asia Cup and Sadio Mane has a calf complaint, keeping him out of this match and with Saints for the time being despite being included in Senegal’s African Nations Cup squad.