The 2009 US Open champion has been sidelined by wrist problems since January, when he returned from surgery in Sydney and reached the quarter-finals.
But he hurt his wrist again, pulling out of the Australian Open, and since then he has been rehabbing after another operation.
The Argentine also had surgery on his right wrist in 2010 and on his left wrist in March last year.
Two months ago, I was leaving the Mayo Clinic after my last surgery. Today I bring you the news: I will play in Miami,” del Potro said.
“With the support of my team and my doctor Richard Berger, I will take another step in the recovery process which, as you know, takes time.”