The former Wimbledon champion beat the world No 44 in four sets in Glasgow to help Great Britain on their way to Davis Cup glory over the United States.
And now the pair go toe-to-toe on the Stadium Court, live on Sky Sports 3 from 3pm, as the Scot seeks to land his first Masters title in two years.
That was an epic three set win against Spain’s David Ferrer, while the Briton also won in Florida in 2009 when he triumphed against Novak Djokovic, although he did finish as runner-up to the Serb three years later.
Third seeded Murray is looking forward to a strong campaign after being dismantled by Australian Open champion Djokovic in the semi-finals at Indian Wells last week.
“I always enjoy it,” said the 27-year-old told Sky Sports. “I obviously spend a lot of time here during the year and I practice all the time in the off season on the Centre Court here so it’s like my home and I always enjoy coming back.
“This year has been good for me – much, much more positive than last year. I obviously lost in the quarter-finals in Australia last year and reached the final this year and played some of the best I have in a long time there.
“I’m happy to be in Miami and hope I can play a good tournament.”
Young, who has a 13-7 win-loss record so far this year, set up a second round meeting with Murray after his opponent Lu Yen-Hsun retired.
The 25-year-old from Atlanta was leading 5-1 in the first set when Lu, of Chinese Taipei, was unable to continue.