Bellucci beat Hewitt in a three hour marathon, 7-5 6-7 (2-7) 6-4, that saw them finish at 1am in Miami.
The Australian veteran failed to capitalize on opportunities to break serve only doing so three times out the 15 on offer.
The difference being that the 27-year-old Bellucci converted on five of nine on the Hewitt serve.
Canadian Vasek Pospisil spoiled Juan Martin del Potro's return from injury with a 6-4 7-6 (9-7) win over the 2009 US Open champion.
After the loss Del Potro said he needed to take the positives from the los after his long lay-off while recovering from injury.
"I don't feel frustrated, I have to take the positive things on my comeback," del Potro said.
Del Potro made an comeback in January before pulling out of the Australian Open because of pain in the wrist and underwent a second surgery two months ago.