Wawrinka has never played a tournament just a week prior to the French Open, which begins on May 24, and is looking to build on his semi-final berth at last week's Rome Masters when he turns out on home soil.
"This is the first time that I have played the week before," the 30-year-old told the official ATP site. "It's a new situation and we will see how it works for me.
"It's great to have a new tournament in Switzerland. It's always nice and important to play in front of your home crowd. If I play well and win matches this will give me more confidence."
Wawrinka is hoping to have an enjoyable and successful week in a setting which he believes makes it easy for players to thrive.
"The tournament is very well organised," he said. "Swiss tournaments are usually very well organised and I don’t say that because I'm Swiss. The quality of the infrastructure, the hotel, the meals and everything is great.
"This morning I practised on Centre Court with my coach [Magnus Norman]. I felt well and now it will be my goal to get ready for my first match."
The 30-year-old, who will be looking to win his fifth clay-court title, will either face Yen-Hsun Lu or Lukas Rosol in the second round after being handed a first-round bye.