Novak Djokovic brought Kyle Edmund's dream run at the US Open to an end on Sunday when he beat the Briton 6-2, 6-1, 6-4.
In the past two rounds, Djokovic has advanced as a result of his opponents succumbing to injury, with Jiri Vesely unable to take to the court in the second round due to inflammation in his left forearm, while Mikhail Youzhny withdrew midway through the opening set of his third-round clash with Djokovic due to a hamstring injury.
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The world number one raced through the first set in 34 minutes, breaking Edmund, who had beaten 13th seed Richard Gasquet, Ernesto Escobedo, and 20th seed John Isner en route to the fourth round. Djokovic kept his foot on the gas in the second set and continued to trouble Edmund, who had no answer to the top seed. Djokovic broke three times in the set to go two sets up.
There was some reason for concern for the Djokovic camp when their man required treatment to a wrist injury when 2-1 up in the third, and a loss of concentration from Djokovic allowed Edmund back into the contest as the pair exchanged breaks.
Djokovic soon regained his composure though and charged to the finish and line. The 29-year-old broke Edmund in the 10th game to book his spot in the last eight and take one step closer to winning his third grand slam of the year, having already triumphed at the Australian Open and Roland Garros.
Djokovic will face Jo-Wilfried Tsonga next in the quarter-finals after the ninth seed defeated 26th seed Jack Sock 6-3, 6-3, 6-7 (7), 6-2.
Tenth seed Gael Monfils also advanced as he triumphed over Marcos Baghdatis 6-3, 6-2, 6-3, but fourth seed Rafael Nadal was the big casualty on Sunday as the Spaniard was beaten by 24th seed Lucas Pouille 1-6, 6-2, 4-6, 6-3, 6-7 (6).